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Nat Rev Drug Discov. 2004 Feb;3(2):125-35.

cAMP detection methods in HTS: selecting the best from the rest.

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  • 1Hit Discovery Group, Pfizer Global Research and Development, Ramsgate Road, Sandwich, Kent CT13 9NJ, UK.


The number of technologies that enable high-throughput functional screening of G-protein-coupled receptors has expanded markedly over the past 5 years. Consequently, choosing the most appropriate technology can be a daunting task, particularly for Gi- or Gs-coupled receptors. The most common systems for cyclic AMP detection are reviewed, highlighting the practical and theoretical aspects that are important in their application to high-throughput screening. Current technologies can do the job, but it is likely that the future may require development of technologies that provide even greater biological information.

[PubMed - indexed for MEDLINE]
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