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Nat Rev Microbiol. 2003 Oct;1(1):65-70.

Where will new antibiotics come from?

Author information

1
Biological Chemistry & Molecular Pharmacology Department, Harvard Medical School, Boston, Massachusetts 02115, USA. christopher_walsh@hms.harvard.edu

Abstract

There is a constant need for new antibacterial drugs owing to the inevitable development of resistance that follows the introduction of antibiotics to the clinic. When a new class of antibiotic is introduced, it is effective at first, but will eventually select for survival of the small fraction of bacterial populations that have an intrinsic or acquired resistance mechanism. Pathogens that are resistant to multiple drugs emerge around the globe, so how robust are antibiotic discovery processes?

PMID:
15040181
DOI:
10.1038/nrmicro727
[Indexed for MEDLINE]

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