Format

Send to

Choose Destination
Yao Xue Xue Bao. 2003 Dec;38(12):911-4.

[Inhibitory action of berberine on glucose absorption].

[Article in Chinese]

Author information

1
Drug Metabolism and Pharmacokinetics Research Center, China Pharmaceutical University, Nanjing 210009, China. panguoyu@hotmail.com

Abstract

AIM:

To study the absorption characteristics of berberine and its influence on glucose absorption.

METHODS:

Rat recirculating perfusion model was used to study berberine absorption characteristics and Caco-2 cell model was used to explore the influence of berberine on disaccharidase, using HPLC to assay the appearance of glucose to indicate enzyme activities.

RESULTS:

Berberine was found to be hardly absorbed in the intestine (less than 5% in 2.5 h). However, sucrase and maltase activities were found to be inhibited by berberine, its ID50 to sucrase is 1.830 mg.L-1, and showed no dose dependent influence on maltase activity. Berberine also showed influence on glucose absorption. However, this effect is not significant.

CONCLUSION:

Berberine may act as an alpha-glucosidase inhibitor, which is its main mechanism in diabetes treatment.

PMID:
15040083
[Indexed for MEDLINE]

Supplemental Content

Loading ...
Support Center