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Infect Immun. 2004 Apr;72(4):2416-9.

Glyceraldehyde-3-phosphate dehydrogenase of Streptococcus pneumoniae is a surface-displayed plasminogen-binding protein.

Author information

1
Research Center for Infectious Diseases, University of Würzburg, Wuerzburg, Germany.

Abstract

The recruitment of plasminogen endows the bacterial cell surface of Streptococcus pneumoniae with proteolytic activity. In this study we demonstrate specific plasmin- and plasminogen-binding activity for the glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase (GAPDH), which is located in the cytoplasm as well as on the surface of pneumococci. GAPDH exhibits a high affinity for plasmin and a significantly lower affinity for plasminogen.

PMID:
15039372
PMCID:
PMC375162
[Indexed for MEDLINE]
Free PMC Article

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