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Reprod Biol Endocrinol. 2004 Mar 23;2:12.

Reactive oxygen species and sperm cells.

Author information

1
Institute of Human Genetics, Polish Academy of Sciences, Poznan, Poland.sanodor@man.poznan.pl

Abstract

There is a dynamic interplay between pro- and anti-oxidant substances in human ejaculate. Excessive reactive oxygen species (ROS) generation can overwhelm protective mechanism and initiate changes in lipid and/or protein layers of sperm plasma membranes. Additionally, changes in DNA can be induced. The essential steps of lipid peroxidation have been listed as well as antioxidant substances of semen. A variety of detection techniques of lipid peroxidation have been summarized together with the lipid components of sperm membranes that can be subjected to stress. It is unsolved, a threshold for ROS levels that may induce functional sperm ability or may lead to male infertility.

PMID:
15038829
PMCID:
PMC400757
DOI:
10.1186/1477-7827-2-12
[Indexed for MEDLINE]
Free PMC Article

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