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J Am Chem Soc. 2004 Mar 31;126(12):3694-5.

Biosynthetic origin of the rare nitroaryl moiety of the polyketide antibiotic aureothin: involvement of an unprecedented N-oxygenase.

Author information

1
Hans-Kn├Âll-Institute for Natural Products Research, Beutenbergstrasse 11a, 07745 Jena, Germany.

Abstract

The antibiotic aureothin is a rare natural nitroaromatic compound produced by Streptomyces thioluteus. By labeling experiments, we demonstrate for the first time that p-nitrobenzoate (PNBA) serves as a polyketide synthase starter unit. Cloning, heterologous expression, and inactivation experiments reveal that this unusual primer is synthesized from p-aminobenzoate (PABA) by means of AurF, a novel N-oxygenase.

PMID:
15038705
DOI:
10.1021/ja039328t
[Indexed for MEDLINE]

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