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Neurology. 2004 Mar 23;62(6):987-9.

Prognostic value of the MIB-1 labeling index for central neurocytomas.

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  • 1Department of Radiation Oncology, University Hospital Hamburg-Eppendorf, Hamburg, Germany.


Although central neurocytomas are generally described as benign CNS lesions, malignant behavior including craniospinal dissemination and tumor-related death may occur. This meta-analysis was performed to investigate the prognostic value of the MIB-1 labeling index. Data were obtained not from the literature alone but also from contact with the authors. The data suggested an MIB-1 index score of >3% to be associated with a worse prognosis for local control (p < 0.0001) and survival (p = 0.0004).

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