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Genes Dev. 2004 Mar 1;18(5):492-7.

Glucocorticoid receptor function in hepatocytes is essential to promote postnatal body growth.

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  • 1Molecular Biology of the Cell I, Deutsches Krebsforschungszentrum, 69120 Heidelberg, Germany.

Abstract

Mice carrying a hepatocyte-specific inactivation of the glucorticoid receptor (GR) gene show a dramatic reduction in body size. Growth hormone signaling mediated by the Stat5 transcription factors is impaired. We show that Stat5 proteins physically interact with GR and GR is present in vivo on Stat5-dependent IGF-I and ALS regulatory regions. Interestingly, mice with a DNA-binding-deficient GR but an unaltered ability to interact with STAT5 (GR(dim/dim)) have a normal body size and normal levels of Stat5-dependent mRNAs. These findings strongly support the model in which GR acts as a coactivator for Stat5-dependent transcription upon GH stimulation and reveal an essential role of hepatic GR in the control of body growth.

PMID:
15037546
PMCID:
PMC374231
DOI:
10.1101/gad.284704
[PubMed - indexed for MEDLINE]
Free PMC Article
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