Format

Send to

Choose Destination
Int Rev Cytol. 2004;233:47-91.

Cellular deflagellation.

Author information

1
Department of Biological Sciences, Simon Fraser University, Burnaby, British Columbia, Canada V5A 1S6.

Abstract

Deciliation, also known as deflagellation, flagellar autotomy, flagellar excision, or flagellar shedding, refers to the process whereby eukaryotic cells shed their cilia or flagella, often in response to stress. Used for many decades as a tool for scientists interested in the structure, function, and genesis of cilia, deciliation itself is a process worthy of scientific investigation. Deciliation has numerous direct medical implications, but more profoundly, intriguing relationships between deciliation, ciliogenesis, and the cell cycle indicate that understanding the mechanism of deciliation will contribute to a deeper understanding of broad aspects of cell biology. This review provides a critical examination of diverse data bearing on this problem. It also highlights current deficiencies in our understanding of the mechanism of deciliation.

PMID:
15037362
DOI:
10.1016/S0074-7696(04)33002-0
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center