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Curr Opin Cell Biol. 2004 Feb;16(1):73-9.

Multiple and surprising new functions for emerin, a nuclear membrane protein.

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  • 1Department of Cell Biology, WBSB room G-9, Johns Hopkins University School of Medicine, 725 N. Wolfe St, Baltimore, MD 21205, USA.


Emerin is an integral protein of the nuclear inner membrane. Emerin is not essential, but its loss of function causes Emery-Dreifuss muscular dystrophy. We summarize significant recent progress in understanding emerin, which was previously known to interact with barrier-to-autointegration factor and lamins. New partners include transcription repressors, an mRNA splicing regulator, a nuclear membrane protein named nesprin, nuclear myosin I and F-actin. These interactors imply multiple roles for emerin in the nucleus, some of which overlap with related LEM-domain proteins.

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