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Ann Epidemiol. 2004 Mar;14(3):229-33.

Distribution of total serum homocysteine and its association with parental history and cardiovascular risk factors at ages 12-16 years: the Third National Health And Nutrition Examination Survey.

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1
Centers for Disease Control and Prevention, Hyattsville, Maryland 20782, USA. RGillum@cdc.gov

Abstract

PURPOSE:

To describe the distribution and to assess the association of serum total homocysteine (tHcy) concentration with variables associated with insulin resistance syndrome in adolescent boys and girls.

METHODS:

In the Third National Health and Nutrition Examination Survey, adolescents aged 12 to 16 years (n = 941) had parental medical history ascertained and glycated hemoglobin, systolic blood pressure, body mass index (BMI), body fat distribution, HDL cholesterol, and serum tHcy concentrations were measured.

RESULTS:

Cumulative distribution of serum tHcy in boys was shifted to the right compared with that in girls. A parental history of high blood pressure or stroke before age 50 was significantly positively associated with the subjects' log serum tHcy after adjustment for confounders (beta 0.156, p = 0.003). Log serum tHcy was significantly positively associated with systolic blood pressure in boys after adjustment for confounders (beta = 0.21, p = 0.03). Log serum tHcy was not significantly associated with glycated hemoglobin percent or most other risk factors other than age. Log serum tHcy concentration showed borderline significant (r = -0.15, p = 0.044) inverse association with BMI in girls.

CONCLUSION:

tHcy was associated with parental history of high blood pressure or stroke before age 50 and with systolic blood pressure in adolescent boys.

PMID:
15036228
DOI:
10.1016/S1047-2797(03)00242-4
[Indexed for MEDLINE]

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