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Cell. 2004 Mar 19;116(6):769-78.

Socializing with the neighbors: stem cells and their niche.

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Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10021, USA.


The potential of stem cells in regenerative medicine relies upon removing them from their natural habitat, propagating them in culture, and placing them into a foreign tissue environment. To do so, it is essential to understand how stem cells interact with their microenvironment, the so-called stem cell niche, to establish and maintain their properties. In this review, we examine adult stem cell niches and their impact on stem cell biology.

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