Abstract
The authors retrospectively review their experience with low immunoglobulin G (IgG) levels in a pediatric ICU population over a 12-month period. The total IgG level was below the normal for age in 14 of the 20 patients. The 14 patients with a low IgG level were younger and weighed less when compared with the 6 patients who had a normal IgG level. There was no difference in the risk of mortality between the 2 groups. In the 14 patients with an IgG level less than normal for age, the IgG level was 33% to 99% of normal, with 4 patients having a level less than 50% of normal for their age. Prospective trials are needed to determine the incidence of this problem, its impact on survival, and the appropriate therapy in the pediatric ICU population.
MeSH terms
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Adolescent
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Adult
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Agammaglobulinemia* / blood
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Agammaglobulinemia* / epidemiology
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Agammaglobulinemia* / etiology
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Agammaglobulinemia* / therapy
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Age Distribution
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Body Weight
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Cardiac Surgical Procedures / adverse effects
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Child
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Child, Preschool
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Critical Care* / methods
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Hospital Mortality
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Hospitals, University
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Humans
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Immunoglobulin G / blood
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Immunoglobulins, Intravenous / therapeutic use
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Incidence
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Infant
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Infant, Newborn
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Intensive Care Units, Pediatric* / statistics & numerical data
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Missouri / epidemiology
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Multiple Organ Failure / complications
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Nephrotic Syndrome / complications
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Reference Values
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Respiratory Distress Syndrome / complications
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Retrospective Studies
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Risk Factors
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Survival Analysis
Substances
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Immunoglobulin G
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Immunoglobulins, Intravenous