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Opt Lett. 2004 Mar 15;29(6):581-3.

Label-free detection of microarrays of biomolecules by oblique-incidence reflectivity difference microscopy.

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1
Department of Physics, National Science Foundation Center for Biophotonics Science & Technology, University of California at Davis, Davis, California 95616, USA.

Abstract

We developed an oblique-incidence reflectivity difference (OI-RD) scanning microscope for label-free imaging of microarrays of biomolecules upon solid substrates. We demonstrate that hybridization reactions in an oligonucleotide microarray fabricated upon a glass slide can be detected by such an OI-RD microscope.

PMID:
15035477
[Indexed for MEDLINE]
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