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Clin Infect Dis. 2004 Apr 1;38(7):e57-62. Epub 2004 Mar 12.

Lower-limb hypoplasia due to intrauterine infection with herpes simplex virus type 2: possible confusion with intrauterine varicella-zoster syndrome.

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1
Neonatal Intensive Care Unit, Hopital Universitaire des Enfants Reine Fabiola, Brussels, Belgium. anne-britt.johansson@huderf.be

Abstract

A neonate with lower-limb hypoplasia, cutaneous scars, bilateral chorioretinitis, and multiple brain abnormalities is presented. Intrauterine herpes simplex virus type 2 (HSV-2) infection was established on the basis of serological testing of the mother and viral cultures of the child's cutaneous lesions, obtained soon after birth. This is, to the best of our knowledge, the first case of a patient with in utero-acquired HSV-2 infection presenting with a limb hypoplasia. It illustrates that, in addition to congenital varicella-zoster syndrome, HSV-2 infection should also be considered in patients presenting with limb hypoplasia.

PMID:
15034848
DOI:
10.1086/382673
[Indexed for MEDLINE]
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