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Ann Hum Genet. 1992 May;56(2):99-103.

Dominant genes for colorectal cancer are not rare.

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Department of Community Medicine, Southampton General Hospital.


The genetic basis for colorectal cancer was investigated by complex segregation analysis of a published series of consecutive pedigrees ascertained through patients undergoing treatment for colorectal cancer. Analysis favoured a dominant gene or genes with a frequency of 0.006 with a lifetime penetrance of 0.63. These genes account for 81% of colorectal cancer in patients under 35, however, by 65 about 85% are phenocopies.

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