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Ann N Y Acad Sci. 2003 Dec;1010:354-7.

Inhibition of apoptosis by amphiregulin via an insulin-like growth factor-1 receptor-dependent pathway in non-small cell lung cancer cell lines.

Author information

1
Groupe de Recherche sur le Cancer du Poumon, INSERM-U578, Institut Albert Bonniot, La Tronche 38706 Cedex, France. amandine.hurbin@ujf-grenoble.fr

Abstract

The reciprocal activation of amphiregulin (AR) and insulin-like growth factor-1 (IGF1) pathways has been shown to induce inhibition of serum deprivation apoptosis in non-small cell lung cancer (NSCLC) cell lines H358 and H322. We demonstrated that AR activated the IGF1 receptor (IGF1-R), which in turn induced the secretion of AR and IGF1. Transactivation of the IGF1-R by AR is independent of its binding to EGFR. Thus, AR can inhibit apoptosis in NSCLC cells through an IGF1-R-dependent pathway.

PMID:
15033751
DOI:
10.1196/annals.1299.065
[Indexed for MEDLINE]

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