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Brain Res. 2004 Apr 9;1004(1-2):203-7.

The vanilloid receptor-1 (TRPV1) is expressed in some rat dorsal horn NK1 cells.

Author information

1
CNRS UMR 7101, Neurobiologie des Signaux Intercellulaires, Université Pierre et Marie Curie, 7 Quai Saint Bernard Bat A 3em, 75252 Paris, France. stephane.doly@snv.jussieu.fr

Abstract

The vanilloid receptor-1 (TRPV1), the capsaicin receptor, a transducer of several nociceptive stimuli, is principally expressed by nociceptive fibers that specifically target supraspinal-projecting neurons expressing the NK1 receptor. TRPV1 is also expressed by intraspinal neurons. Using double immunocytochemistry, we show that 14.2% of these TRPV1 dorsal horn cell bodies also express the NK1 receptor suggesting that endogenous vanilloids may directly modulate second-order ascending neurons.

PMID:
15033437
DOI:
10.1016/j.brainres.2004.01.023
[Indexed for MEDLINE]

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