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Annu Rev Immunol. 2004;22:485-501.

RAGs and regulation of autoantibodies.

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Laboratory of Molecular Immunology, The Rockefeller University, New York, New York 10021, USA.


Autoreactive antibodies are etiologic agents in a number of autoimmune diseases. Like all other antibodies these antibodies are produced in developing B cells by V(D)J recombination in the bone marrow. Three mechanisms regulate autoreactive B cells: deletion, receptor editing, and anergy. Here we review the prevalence of autoantibodies in the initial antibody repertoire, their regulation by receptor editing, and the role of the recombinase proteins (RAG1 and RAG2) in this process.

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