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EMBO J. 2004 Mar 24;23(6):1325-35. Epub 2004 Mar 18.

JunD regulates lymphocyte proliferation and T helper cell cytokine expression.

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1
Research Institute of Molecular Pathology (IMP), Vienna, Austria.

Abstract

Transgenic mice broadly expressing JunD (Ubi-junD(m)) appear phenotypically normal, but have strongly reduced numbers of peripheral lymphocytes. JunD overexpression in lymphocytes does not protect from numerous apoptotic insults; however, transgenic T cells proliferate poorly and exhibit impaired activation due to reduced levels of IL-4, CD25 and CD69. Consistently, in the absence of JunD (junD(-/-)) T cells hyperproliferate following mitogen induction. Moreover, transgenic T helper (Th) 2 cells have decreased IL-4 and IL-10 expression, whereas junD(-/-) Th2 cells secrete higher amounts of both Th2 cytokines. Th1-polarized junD(-/-) CD4(+) T cells display enhanced IFN-gamma cytokine production associated with upregulated T-bet expression and downregulated expression of suppressor of cytokine signaling-1. These novel findings demonstrate a regulatory role of JunD in T lymphocyte proliferation and Th cell differentiation.

PMID:
15029240
PMCID:
PMC381408
DOI:
10.1038/sj.emboj.7600133
[Indexed for MEDLINE]
Free PMC Article
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