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Trends Biochem Sci. 1992 Jun;17(6):219-23.

Bacterial protein translocation: kinetic and thermodynamic role of ATP and the protonmotive force.

Author information

1
Department of Microbiology, University of Groningen, Haren, The Netherlands.

Abstract

The energetic mechanism of preprotein export in Escherichia coli has been a source of controversy for many years. In vitro studies of translocation reactions that use purified soluble and membrane components have not clarified the main features of this mechanism. Translocation occurs through consecutive steps which each have distinct energy requirements. Initiation of translocation requires ATP and the SecA protein. Most of the further steps can be driven by the protonmotive force (delta p).

PMID:
1502724
DOI:
10.1016/0968-0004(92)90381-i
[Indexed for MEDLINE]

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