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Sci STKE. 2004 Mar 9;2004(224):pe10.

Sensing cellular stress: another new function for the nucleolus?

Author information

1
Department of Biochemistry, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, USA. molson@biochem.umsmed.edu

Abstract

Recent research suggests that the nucleolus communicates with the p53 regulatory system and acts as a stress sensor. Cellular stress causes nucleolar disruption, triggering the release of regulatory factors to the nucleoplasm. These factors, especially ARF (alternative reading frame), inhibit the degradation of p53, thereby facilitating its intracellular accumulation.

PMID:
15026578
DOI:
10.1126/stke.2242004pe10
[Indexed for MEDLINE]

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