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Bioorg Med Chem Lett. 2004 Apr 5;14(7):1619-24.

Discovery and SAR of trisubstituted thiazolidinones as CCR4 antagonists.

Author information

1
Array BioPharma, 3200 Walnut Street, Boulder, CO 80301, USA.

Abstract

Substituted thiazolidinones were identified as CCR4 antagonists from high throughput screening. Subsequent lead optimization efforts resulted in defined structure-activity relationships and the identification of potent antagonists (compounds 90 and 91) that inhibited the chemotaxis of Th2 T-cells in vitro.

PMID:
15026036
DOI:
10.1016/j.bmcl.2004.01.072
[Indexed for MEDLINE]

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