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Pflugers Arch. 2004 Jun;448(3):296-303. Epub 2004 Mar 13.

Nitrosative stress and potassium channel-mediated neuronal apoptosis: is zinc the link?

Author information

1
Department of Neurobiology, University of Pittsburgh School of Medicine, E1456 BST, Pittsburgh, PA 15261, USA.

Abstract

Nitrosative stress has been implicated in a large number of neurological disorders. The molecular mechanisms underlying the neuronal injury associated with this stimulus, however, are not clearly understood. Emerging evidence suggests that the liberation of intracellular zinc as well as over-activation of potassium channels may be two important components of nitrosative stress-induced neuronal death.

PMID:
15024658
PMCID:
PMC2945503
DOI:
10.1007/s00424-004-1256-7
[Indexed for MEDLINE]
Free PMC Article

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