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Nat Struct Mol Biol. 2004 Apr;11(4):380-1. Epub 2004 Mar 14.

A receptor for green tea polyphenol EGCG.

Author information

1
Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Hakozaki 6-10-1, Fukuoka, 812-8581, Japan. tatibana@agr.kyushu-u.ac.jp

Abstract

The major polyphenol in green tea, (-)-epigallocatechin-3-gallate (EGCG), has been shown to prevent carcinogenesis. We have identified a receptor that mediates the anticancer activity of EGCG. Expression of the metastasis-associated 67-kDa laminin receptor confers EGCG responsiveness to cancer cells at physiologically relevant concentrations. Experiments using surface plasmon resonance demonstrate binding of EGCG to the 67-kDa laminin receptor with a nanomolar K (d) value.

PMID:
15024383
DOI:
10.1038/nsmb743
[Indexed for MEDLINE]

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