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Arch Neurol. 2004 Mar;61(3):366-8.

A preliminary diffusion tensor and magnetization transfer magnetic resonance imaging study of early-onset multiple sclerosis.

Author information

1
Neuroimaging Research Unit and the Department of Neurology, Scientific Institute and University Hospital San Raffaele, Milan, Italy.

Abstract

BACKGROUND:

Early-onset multiple sclerosis (MS) typically has a more favorable course than adult-onset disease.

OBJECTIVE:

To assess the extent of microscopic tissue damage in the brain and cervical cord of patients with early-onset MS.

DESIGN:

During a single magnetic resonance imaging session, images of the brain and spinal cord were obtained using diffusion tensor and magnetization transfer magnetic resonance imaging.

PATIENTS:

We studied 13 patients with early-onset MS and 10 healthy volunteers.

RESULTS:

Compared with control subjects, patients with early-onset MS showed only a slight increase of the average mean diffusivity of the normal-appearing brain tissue.

CONCLUSION:

The relatively modest central nervous system damage detected in these patients might explain why early-onset MS typically has a more favorable clinical course than adult-onset MS.

PMID:
15023813
DOI:
10.1001/archneur.61.3.366
[Indexed for MEDLINE]

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