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Acta Orthop Scand. 2004 Feb;75(1):93-9.

Platelet concentrate injection improves Achilles tendon repair in rats.

Author information

1
Orthopedics and Sports Medicine, Department of Neuroscience and Locomotion, Faculty of Health Science, SE-581 85 Linköping, Sweden. per.aspenberg@inr.liu.se

Abstract

BACKGROUND:

Blood platelets release a cocktail of growth factors when activated, some of which are thought to initiate and stimulate repair.

EXPERIMENT AND FINDINGS:

We studied whether a platelet concentrate injection would improve Achilles tendon repair in an established rat model. The Achilles tendon was transected and a 3 mm segment removed. After 6 h, a platelet concentrate was injected percutaneously into the hematoma. This increased tendon callus strength and stiffness by about 30% after 1 week, which persisted for as long as 3 weeks after the injection. At this time, the mechanical testing indicated an improvement in material characteristics--i.e., greater maturation of the tendon callus. This was confirmed by blinded histological scoring.

INTERPRETATION:

Platelet concentrate may prove useful for the treatment of Achilles tendon ruptures.

PMID:
15022816
DOI:
10.1080/00016470410001708190
[Indexed for MEDLINE]

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