[Analysis of the mutagenic activity examplified by interaction of DNA bases with nitrous acid]

Klin Lab Diagn. 2004 Jan:(1):15-8.
[Article in Russian]

Abstract

Chromatography and spectrophotometry techniques were designed to evaluate both qualitatively and quantitatively a degree of DNA-base deamination provoked by nitric acid. A possibility is shown of how to apply the above method in studying the mutagene activity of deaminating agents.

Publication types

  • English Abstract

MeSH terms

  • Adenine / chemistry
  • Chromatography, Thin Layer
  • Cytosine / chemistry
  • DNA / chemistry*
  • Hypoxanthine / chemistry
  • Mutagenicity Tests / methods*
  • Nitrous Acid / chemistry*
  • Spectrometry, Fluorescence
  • Uracil / chemistry

Substances

  • Hypoxanthine
  • Uracil
  • Cytosine
  • DNA
  • Adenine
  • Nitrous Acid