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Oncogene. 2004 Mar 15;23(11):2028-36.

The many faces of beta-TrCP E3 ubiquitin ligases: reflections in the magic mirror of cancer.

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1
Department of Animal Biology, University of Pennsylvania, 3800 Spruce Street, Rm 161E, Philadelphia, PA 19104, USA. sfuks@vet.upenn.edu

Abstract

Beta-transducin repeats-containing proteins (beta-TrCP) serve as the substrate recognition subunits for the SCFbeta-TrCP E3 ubiquitin ligases. These ligases ubiquitinate specifically phosphorylated substrates and play a pivotal role in the regulation of cell division and various signal transduction pathways, which, in turn, are essential for many aspects of tumorigenesis. We review the functions of the SCFbeta-TrCP ligases in the light of their relevance to cell growth, survival and transformation. Mechanisms underlying beta-TrCP regulation and their aberration in human and animal cancer as well as prospective of targeting beta-TrCP as a means of anticancer therapy are also discussed.

PMID:
15021890
DOI:
10.1038/sj.onc.1207389
[Indexed for MEDLINE]
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