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Ann Rheum Dis. 2004 Apr;63(4):402-7.

Reduced functional performance in the lower extremity predicted radiographic knee osteoarthritis five years later.

Author information

1
Spenshult Hospital for Rheumatic Diseases, Oskarström, Sweden. carina.thorstensson@spenshult.se

Abstract

BACKGROUND:

Reduced quadriceps strength is an early finding in subjects with knee osteoarthritis, but it is not clear whether it is a cause or a consequence of knee osteoarthritis.

OBJECTIVE:

To determine whether reduced functional performance in the lower extremity predicts the incidence or progression of radiographic knee osteoarthritis.

DESIGN:

Prospective, epidemiological, population based cohort study.

PATIENTS:

148 subjects (62 women), aged 35-54 (mean 44.8), with chronic knee pain from a population based cohort.

MEASUREMENTS:

Predictors analysed were age, sex, body mass index, baseline knee pain, and three tests of lower extremity functional performance: maximum number of one-leg rises from sitting, time spent walking 300 m, and timed standing on one leg. Weightbearing tibiofemoral knee radiographs were obtained at baseline and after 5 years (median 5.1, range 4.2-6.1), and classified according to Kellgren and Lawrence as no osteoarthritis (Kellgren and Lawrence = 0, n = 94) or prevalent osteoarthritis (Kellgren and Lawrence >/=1, n = 54).

RESULTS:

Fewer one-leg rises (median 17 v 25) predicted incident radiographic osteoarthritis five years later (OR 2.6, 95% CI 1.1 to 6.0). The association remained significant after controlling for age, sex, body mass index, and pain. No significant predictor of radiographic progression in the group with prevalent osteoarthritis was found.

CONCLUSION:

Reduced functional performance in the lower extremity predicted development of radiographic knee osteoarthritis 5 years later among people aged 35-55 with chronic knee pain and normal radiographs at baseline. These findings suggest that a test of one-leg rises may be useful, and interventions aimed at improving functional performance may be protective against development of knee osteoarthritis.

PMID:
15020334
PMCID:
PMC1754965
[Indexed for MEDLINE]
Free PMC Article
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