Mi-2/NuRD: multiple complexes for many purposes

Biochim Biophys Acta. 2004 Mar 15;1677(1-3):52-7. doi: 10.1016/j.bbaexp.2003.10.010.

Abstract

The vertebrate Mi-2/NuRD complex is a multi-subunit protein complex containing both histone deacetylase and nucleosome-dependent ATPase subunits. Current models predict that this complex functions primarily in transcriptional repression. Surprisingly, every subunit of this complex presents heterogeneity at the protein and gene level. This raises the intriguing possibility of functional specialization resulting from incorporation of unique gene products into the complex. The MTA (metastasis-associated) proteins represent one class of alternative subunits of the human Mi-2/NuRD complex. The members of this family in human cells are differentially expressed depending on cell type and on physiologic parameters. We summarize evidence supporting the view that the alternative subunits of the complex that have arisen during vertebrate evolution endow unique functional properties.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Adenosine Triphosphatases / genetics
  • Adenosine Triphosphatases / metabolism*
  • Amino Acid Sequence
  • Animals
  • Autoantigens / genetics
  • Autoantigens / metabolism
  • Carrier Proteins / genetics
  • Carrier Proteins / metabolism
  • DNA Helicases / genetics
  • DNA Helicases / metabolism*
  • DNA Methylation
  • DNA-Binding Proteins / genetics
  • DNA-Binding Proteins / metabolism
  • Drosophila Proteins / genetics
  • Drosophila Proteins / metabolism
  • Histone Deacetylases / genetics
  • Histone Deacetylases / metabolism*
  • Humans
  • Macromolecular Substances
  • Mi-2 Nucleosome Remodeling and Deacetylase Complex
  • Molecular Sequence Data
  • Neoplasm Proteins / genetics
  • Neoplasm Proteins / metabolism
  • Phylogeny
  • Protein Isoforms
  • Repressor Proteins / genetics
  • Repressor Proteins / metabolism
  • Trans-Activators
  • Transcription Factors

Substances

  • Autoantigens
  • Carrier Proteins
  • DNA-Binding Proteins
  • Drosophila Proteins
  • MBD2 protein
  • MBD3 protein, human
  • MTA3 protein, human
  • Macromolecular Substances
  • Mbd3 protein, mouse
  • Mi-2 protein, Drosophila
  • MTA1 protein, human
  • Neoplasm Proteins
  • Protein Isoforms
  • Repressor Proteins
  • Trans-Activators
  • Transcription Factors
  • MTA2 protein, human
  • Histone Deacetylases
  • Mi-2 Nucleosome Remodeling and Deacetylase Complex
  • Adenosine Triphosphatases
  • DNA Helicases
  • CHD3 protein, human