Format

Send to

Choose Destination
Peptides. 2003 Nov;24(11):1681-91.

The relationship between peptide structure and antibacterial activity.

Author information

1
Department of Microbiology and Immunology, University of British Columbia, #300-6174 University Boulevard, Vancouver, BC, Canada V6T 1Z3. bob@cmdr.ubc.ca

Abstract

Cationic antimicrobial peptides are a class of small, positively charged peptides known for their broad-spectrum antimicrobial activity. These peptides have also been shown to possess anti-viral and anti-cancer activity and, most recently, the ability to modulate the innate immune response. To date, a large number of antimicrobial peptides have been chemically characterized, however, few high-resolution structures are available. Structure-activity studies of these peptides reveal two main requirements for antimicrobial activity, (1) a cationic charge and (2) an induced amphipathic conformation. In addition to peptide conformation, the role of membrane lipid composition, specifically non-bilayer lipids, on peptide activity will also be discussed.

PMID:
15019199
DOI:
10.1016/j.peptides.2003.08.023
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center