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Curr Opin Neurobiol. 2004 Feb;14(1):96-104.

Activity-dependent organization of inhibitory circuits: lessons from the auditory system.

Author information

1
Department of Neurobiology, University of Pittsburgh School of Medicine, 3500 Terrace Street, Pittsburgh, PA 15261, USA. kkarl@pitt.edu

Abstract

In contrast to our detailed knowledge about the development and plasticity of excitatory neuronal circuits, little is known about the development of inhibitory circuits. Recent studies from the developing mammalian auditory system have revealed the presence of substantial activity-dependent synaptic reorganization in several inhibitory pathways. These studies importantly shed some new light on the general rules and cellular mechanisms that manage the organization of precise inhibitory circuits in the developing brain.

PMID:
15018944
DOI:
10.1016/j.conb.2004.01.017
[Indexed for MEDLINE]

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