Format

Send to

Choose Destination
Curr Opin Neurobiol. 2004 Feb;14(1):51-60.

The optic chiasm as a midline choice point.

Author information

1
Department of Pathology, Center for Neurobiology and Behavior, Columbia University, College of Physicians and Surgeons, 630 W. 168(th) Street, New York, NY 10032, USA.

Abstract

The mouse optic chiasm is a model for axon guidance at the midline and for analyzing how binocular vision is patterned. Recent work has identified several molecular players that influence the binary decision that retinal ganglion cells make at the optic chiasm, to either cross or avoid the midline. An ephrin-B localized to the midline, together with an EphB receptor and a zinc-finger transcription factor expressed exclusively in the ventrotemporal retina where ipsilaterally projecting retinal ganglion cells are located, comprise a molecular program for the uncrossed pathway. In addition, the mechanisms for axon divergence in the optic chiasm are discussed in the context of other popular models for midline axon guidance.

PMID:
15018938
DOI:
10.1016/j.conb.2004.01.010
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center