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Oncogene. 1992 Sep;7(9):1783-92.

Max and c-Myc/Max DNA-binding activities in cell extracts.

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Biochemistry of the Cell Nucleus Laboratory, Imperial Cancer Research Fund, London, UK.


We have examined the interactions and DNA-binding activities of the c-Myc oncoprotein and its partner Max. In cell extracts virtually all c-Myc molecules are associated with Max in heterodimeric complexes. Moreover, DNA-binding studies with in vitro-translated protein and cell extracts show that both Max alone and c-Myc/Max bind the same DNA sequence. Conversely, c-Myc is unable to bind this sequence in the absence of Max. These findings suggest that c-Myc may function via obligate complex formation with Max.

[Indexed for MEDLINE]

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