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Pediatr Dev Pathol. 2003 Nov-Dec;6(6):558-63.

Acute lymphoblastic leukemia with hypereosinophilia: report of a case with 5q deletion and review of the literature.

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  • 1Section of Hematology/Oncology, Columbus Children's Hospital, 700 Children's Drive, Columbus, OH 43205, USA.


Peripheral blood eosinophilia as a presentation of acute lymphoblastic leukemia (ALL) has only rarely been reported. The eosinophilia is thought to be a nonneoplastic reaction to the neoplastic lymphoblasts. We present the case of a 5-year-old girl who developed peripheral hypereosinophilia with no circulating blasts prior to her diagnosis of B-cell lineage ALL. Cytogenetic study showed a hyperdiploid blast population with 5q deletion. Persistent peripheral hypereosinophilia should always be fully investigated, the possibility of a malignancy including ALL needs to be excluded, even in the absence of peripheral cytopenias and circulating blasts.

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