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News Physiol Sci. 2004 Apr;19:44-50.

Calcium and TRP channels in pulmonary vascular smooth muscle cell proliferation.

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1
Department of Medicine, School of Medicine, University of California, San Diego, California 92103, USA.

Abstract

Ca(2+) is a major trigger for pulmonary vasoconstriction and a stimulus for pulmonary vascular smooth muscle cell proliferation. The transient receptor potential cation channels participate in regulating intracellular Ca(2+) and thus vascular contractility and cell proliferation. Upregulation of genes encoding these channels is involved in the development of pulmonary hypertension.

PMID:
15016901
[Indexed for MEDLINE]
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