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Pediatr Diabetes. 2001 Dec;2(4):191-4.

Use of hypertonic saline in the treatment of cerebral edema in diabetic ketoacidosis (DKA).

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1
Department of Pediatrics, Division of Endocrinology, The Hospital for Sick Children, The University of Toronto, Toronto, Ontario, Canada. Jacqueline.curtis@sickkids.on.ca

Abstract

Cerebral edema is the primary cause of morbidity and mortality in children and adolescents with diabetic ketoacidosis (DKA). We report a case of an adolescent female with life-threatening DKA-related cerebral edema who responded to a combination of mannitol and hypertonic saline. This is the first report of the use of hypertonic saline in the treatment of cerebral edema due to DKA.

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