Unusual metastatic features in a patient with concomitant malignant orbital melanoma and prostate carcinoma

J Neurooncol. 2004 Feb;66(3):361-3. doi: 10.1023/b:neon.0000014540.05737.1a.

Abstract

A 73-year-old man with a history of malignant orbital melanoma and prostate carcinoma was admitted for progressive visual disturbance. Brain magnetic resonance imaging showed a suprasellar enhancing nodular lesion with major impingement on the anterior optical ways and sellar invasion. The extensive imaging work-up could not demonstrate with certainty its origin. Surprisingly, the transphenoidal biopsy of this patient revealed a prostate cancer metastasis outlining the importance of a histopathological diagnosis of cerebral metastases in patients with multiple malignancies when there is a doubt about the nature of the lesion.

Publication types

  • Case Reports

MeSH terms

  • Adenocarcinoma / chemistry
  • Adenocarcinoma / secondary*
  • Aged
  • Biomarkers, Tumor / analysis
  • Brain Neoplasms / chemistry
  • Brain Neoplasms / secondary
  • Humans
  • Lymphatic Metastasis
  • Magnetic Resonance Imaging
  • Male
  • Melanoma / chemistry
  • Melanoma / secondary*
  • Neoplasms, Multiple Primary / pathology*
  • Orbital Neoplasms / chemistry
  • Orbital Neoplasms / pathology*
  • Pituitary Neoplasms / chemistry
  • Pituitary Neoplasms / secondary*
  • Prostatic Neoplasms / chemistry
  • Prostatic Neoplasms / pathology*

Substances

  • Biomarkers, Tumor