Format

Send to

Choose Destination
EMBO J. 2004 Apr 7;23(7):1433-40. Epub 2004 Mar 11.

Myo1c is designed for the adaptation response in the inner ear.

Author information

1
Division of Physical Biochemistry, National Institutes for Medical Research, The Ridgeway, Mill Hill, London, UK.

Abstract

The molecular motor, Myo1c, a member of the myosin family, is widely expressed in vertebrate tissues. Its presence at strategic places in the stereocilia of the hair cells in the inner ear and studies using transgenic mice expressing a mutant Myo1c that can be selectively inhibited implicate it as the mediator of slow adaptation of mechanoelectrical transduction, which is required for balance. Here, we have studied the structural, mechanical and biochemical properties of Myo1c to gain an insight into how this molecular motor works. Our results support a model in which Myo1c possesses a strain-sensing ADP-release mechanism, which allows it to adapt to mechanical load.

PMID:
15014434
PMCID:
PMC391074
DOI:
10.1038/sj.emboj.7600169
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for HighWire Icon for PubMed Central
Loading ...
Support Center