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Am J Ophthalmol. 2004 Mar;137(3):554-6.

Ocular vaccinia following exposure to a smallpox vaccinee.

Author information

1
Ocular Inflammatory Disease Center, Jules Stein Eye Institute and Department of Ophthalmology, Los Angeles, California 90095-1688, USA. dpegues@mednet.ucla.edu

Abstract

PURPOSE:

To describe the presentation and management of the first identified case of ocular vaccinia infection associated with the current smallpox vaccination program.

DESIGN:

Case report.

METHODS:

Vaccinia virus was isolated by cell culture of a conjunctival swab. Direct staining with fluorescein isothiocyanate-labeled vaccinia antibody and polymerase chain reaction testing confirmed the diagnosis.

RESULTS:

In February 2003, a 26-year-old woman developed right preseptal cellulitis and blepharoconjunctivitis following contact with a vaccinated member of the military. The preseptal cellulitis resolved with antibacterial therapy, and the conjunctival infection was treated successfully with a 14-day course of topical trifluridine and a single dose of intravenous vaccinia immune globulin.

CONCLUSIONS:

To facilitate rapid diagnosis and appropriate treatment, clinicians must maintain a high index of suspicion for ocular smallpox vaccine-associated adverse reactions in vaccine recipients and their close contacts.

PMID:
15013881
DOI:
10.1016/j.ajo.2003.09.013
[Indexed for MEDLINE]

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