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Biol Psychiatry. 2004 Mar 15;55(6):648-51.

Frontal lobe gray matter density decreases in bipolar I disorder.

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1
Brain Imaging Center, McLean Hospital, Belmont, Massachusetts 02478, USA.

Abstract

BACKGROUND:

This study was conducted to explore differences in gray and white matter density between bipolar and healthy comparison groups using voxel-based morphometry (VBM).

METHODS:

Brain magnetic resonance imaging was performed for 39 subjects with bipolar I disorder and 43 comparison subjects. Images were registered into a proportional stereotaxic space and segmented into gray matter, white mater, and cerebrospinal fluid. Statistical parametric mapping was used to calculate differences in gray and white matter density between groups.

RESULTS:

Bipolar subjects had decreased gray matter density in left anterior cingulate gyrus (Brodmann's area [BA] 32, 7.3% decrease), an adjacent left medial frontal gyrus (BA 10, 6.9% decrease), right inferior frontal gyrus (BA 47, 9.2% decrease), and right precentral gyrus (BA 44, 6.2% decrease), relative to comparison subjects.

CONCLUSIONS:

The observation of a gray matter density decrease in the left anterior cingulate, which processes emotions, in bipolar subjects is consistent with prior reports that used region-of-interest analytic methods. Decreased gray matter density in the right inferior frontal gyrus, which processes nonverbal and intrinsic functions, supports nondominant hemisphere dysfunction as a component of bipolar disorder.

PMID:
15013835
DOI:
10.1016/j.biopsych.2003.10.017
[Indexed for MEDLINE]
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