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Mutat Res. 2004 Mar 22;547(1-2):19-33.

A statistical treatment of biases affecting the estimation of mutation rates.

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1
Dipartimento di Economia, Università Roma Tre, Via Ostiense 139, 00154 Roma, Italy.

Abstract

We consider the estimation of mutation rates, using family data obtained from disputed paternity cases. It is shown how to take appropriate account of a number of complicating features-in particular, hidden mutation, differential mutation, and uncertain paternity-which can necessitate large corrections to simple estimates.

PMID:
15013695
DOI:
10.1016/j.mrfmmm.2003.11.005
[Indexed for MEDLINE]
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