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Org Lett. 2004 Mar 18;6(6):1049-52.

Berkeleydione and berkeleytrione, new bioactive metabolites from an acid mine organism.

Author information

1
Department of Chemistry, Montana Tech of the University of Montana, Butte, Montana 59701, USA. dstierle@mtech.edu

Abstract

[structure: see text] Two novel hybrid polyketide-terpenoid metabolites were isolated from a Penicillium sp. growing in the Berkeley Pit Lake of Butte, Montana. Their structures were deduced by spectroscopic analysis and confirmed by single-crystal X-ray analysis on berkeleydione (1). Both compounds inhibited matrix metalloproteinase-3 and caspase-1, and berkeleydione showed activity toward non-small-cell lung cancer in NCI's human cell line antitumor screen.

PMID:
15012097
DOI:
10.1021/ol049852k
[Indexed for MEDLINE]
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