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Lab Chip. 2004 Feb;4(1):24-7. Epub 2004 Jan 5.

Poly(dimethylsiloxane) hollow Abbe prism with microlenses for detection based on absorption and refractive index shift.

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Institut für Mikrotechnik, Technische Universität Braunschweig, Alte Salzdahlumer Strassee 203, 38124 Braunschweig, Germany.


In this paper we report on an optical detection method that utilizes two physical effects for signal transduction, namely absorption and shift of refractive index. The device consists of a hollow prism and was fabricated by means of soft-lithography. It exhibits a high degree of monolithic integration. In order to keep down the amount of external equipment that is necessary to run the device, we were able to integrate several functions, such as focussing of light and alignment of optical fibres. Since all components are fabricated in the same material and in the same process, compatibility with other microfluidic devices or components can be achieved easily. The functional efficiency and the performance of the detector were tested by investigating solutions containing fluorescein, with concentrations between 5 and 1000 microM. The results clearly show the two regions in which the two physical effects are effective.

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