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Bioorg Med Chem Lett. 2004 Mar 22;14(6):1417-21.

Estrogen receptor ligands. Part 1: The discovery of flavanoids with subtype selectivity.

Author information

1
Department of Medicinal Chemistry, Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065, USA. helen_chen@merck.com

Abstract

A class of flavanoids exhibiting a high degree of selectivity for ERalpha over ERbeta has been discovered. The most active analogue 6 was found to be 66-fold ERalpha-selective and demonstrated uterine estradiol antagonism.

PMID:
15006374
DOI:
10.1016/j.bmcl.2004.01.031
[Indexed for MEDLINE]

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