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Cell. 2004 Mar 5;116(5):699-709.

Identification and distinct regulation of yeast TATA box-containing genes.

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1
Graduate Program in Statistics, The Pennsylvania State University, University Park, PA 16802, USA.

Erratum in

  • Cell. 2004 Jun 11;117(6):847.

Abstract

Despite being one of the first eukaryotic transcriptional regulatory elements identified, the sequence of a native TATA box and its significance remain elusive. Applying criteria associated with TATA boxes we queried several Saccharomyces genomes and arrived at the consensus TATA(A/T)A(A/T)(A/G). Approximately 20% of yeast genes contain a TATA box. Strikingly, TATA box-containing genes are associated with responses to stress, are highly regulated, and preferentially utilize SAGA rather than TFIID when compared to TATA-less promoters. Transcriptional regulation in yeast appears to be mechanistically bipolar, possibly reflecting a need to balance inducible stress-related responses with constitutive housekeeping functions.

PMID:
15006352
[Indexed for MEDLINE]
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