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Psychopharmacology (Berl). 2004 Apr;173(1-2):18-26. Epub 2004 Mar 5.

Do smokers self-administer pure nicotine? A review of the evidence.

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1
Department of Psychology, Tel Aviv University, 69978 Tel Aviv, Israel.ruvidar@freud.tau.ac.il

Abstract

RATIONALE:

Nicotine is almost universally believed to be the primary agent motivating tobacco smoking and the main impediment to cessation. A principal argument in support of the presumed reinforcing properties of nicotine is that smokers self-administer pure nicotine. However, the evidence for nicotine self-administration in smokers has not been critically examined.

OBJECTIVES:

To review and examine the empirical basis for the assertion that smokers self-administer pure nicotine.

METHODS:

We reviewed all the studies we were able to locate that are cited as demonstrating self-administration of nicotine, isolated from tobacco, in normal smokers and non-smokers. These studies investigated self-administration of intravenous nicotine, nicotine gum and nicotine spray. Using the authors' own criteria, we examined whether these studies in fact demonstrate nicotine-self administration.

RESULTS:

None of the studies we reviewed demonstrated nicotine self-administration in smokers. Both smokers and non-smokers failed to show preference for nicotine over placebo in any of these studies, including in a series of six reports of overnight abstinent smokers having access to nicotine nasal spray, a rapidly absorbed form of nicotine.

CONCLUSIONS:

The common statement that smokers self-administer pure nicotine lacks empirical support. Smokers in fact do not administer pure nicotine in any of the forms studied to date, even when abstinent and presumably nicotine-deprived. This conclusion necessitates a critical re-examination of the nicotine addiction thesis.

PMID:
15004737
DOI:
10.1007/s00213-004-1781-2
[Indexed for MEDLINE]
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