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Gynecol Obstet Invest. 2004;58(1):14-8. Epub 2004 Mar 5.

Matrix metalloproteinases of human leiomyoma in various stages of tumor growth.

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Department of Medical Biochemistry, Medical Academy of Białystok, Białystok, Poland.


The amounts and activities of matrix metalloproteinases (MMPs) were studied in human myometrium and uterine leiomyomas in various stages of growth. It was found that both myometrium and the investigated tumors contain collagenolytic enzymes. MMP-1, MMP-2, MMP-3 and MMP-9 were found. Gelatinase A (MMP-2) is the most abundant. In control myometrium only 10% of this enzyme exists in an active form, whereas in tumors, especially in large ones, the values reach 30%. It is suggested that the high activity of MMP-2 is responsible for remodelling of extracellular matrix in the growing tumors.

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