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Biochem Biophys Res Commun. 2004 Mar 26;316(1):240-3.

IGF-I regulates caveolin 1 and IRS1 interaction in caveolae.

Author information

1
Department of Endocrinology and Metabolism, University of Genova, Genoa, Italy.

Abstract

Caveolae are hot spots in IGF-I signalling as suggested by the facts that IGF-I receptors localize in caveolae, directly interact with and tyrosine phosphorylate caveolin 1, the major caveolar protein. Also a number of IGF-IR substrates reside in caveolae, supporting a role of these organelles in the regulation of IGF-I action. Recently, we have demonstrated that IGF-I could specifically regulate Shc phosphorylation in caveolae. Here we show that also IRS1 localizes in this region where it is tyrosine phosphorylated in the presence of IGF-I. Moreover, IRS1 co-immunoprecipitates with caveolin 1 and the specific phosphocaveolin 1-IRS1 interaction is increased by IGF-I.

PMID:
15003536
DOI:
10.1016/j.bbrc.2004.02.037
[Indexed for MEDLINE]

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